Emergency warfarin reversal with prothrombin complex concentrates: UK wide study

Prothrombin complex concentrates in warfarin anticoagulation reversal

Anticoagulation is very effective for primary and secondary prevention of thromboembolic events. However, questions persist about the risks and management of over-anticoagulation. The annual incidence of major bleeding in trials and cohort studies has been reported to be between 1.1% and 2.3% in patients treated with warfarin to achieve an international normalized ratio (INR) of 2.0 to 3.0. The...

Rapid reversal of warfarin-associated hemorrhage in the emergency department by prothrombin complex concentrates.

Life-threatening warfarin-associated hemorrhage is common, with a high mortality. In the United States, the most commonly used therapies--fresh frozen plasma and vitamin K--are slow and unpredictable and can result in volume overload. Outside of the United States, prothrombin complex concentrates are often used instead; these pooled plasma products reverse warfarin anticoagulation in minutes ra...

Prothrombin complex concentrates utility for warfarin-associated hemorrhage.

INTRODUCTION Prothrombin Complex Concentrate (PCC) for reversal of warfarin is the main therapeutic option in cases of life-threatening bleeding. Aim of the study was to investigate for using 4-factor PCC brought to the therapeutic levels of International Normalized Ratio (INR) values in cases of life-threatening bleeding in Emergency Department. METHODS This retrospective cohort study was pe...

Outcomes of urgent warfarin reversal with frozen plasma versus prothrombin complex concentrate in the emergency department.

BACKGROUND Physicians reverse patients' warfarin anticoagulation with frozen plasma or prothrombin complex concentrate. Our objective was to determine adverse event frequency after urgent reversal with frozen plasma versus the prothrombin complex concentrate Octaplex. METHODS AND RESULTS This natural before-after retrospective cohort study in 2 tertiary care emergency departments compared ant...

Use of prothrombin complex concentrates for urgent reversal of dabigatran in the Emergency Department.